Pain and Inflammation.

Pain is the most common reason people seek medical attention and miss work. Lost workdays due to pain and current treatment are estimated to cost the US economy $100 billion each year. Pain is caused by a complex cascade of events that stimulates specific nerves known as nociceptors. Pain can be caused by mechanical (touch), thermal (heat/cold), chemical, or ischemic (low blood flow) damage.

Current treatment.

Treatment of pain has largely remained unchanged for the last 20 years. Opioid derivatives (morphine, hydrocodone) and non-steroidal anti-inflammatory drugs (NSAIDs) remain the cornerstone of pain management but are associated with serious side effects that include addiction and increased risk of bleeding and cardiovascular events.

New opportunities.

Kalypsys is developing novel mechanism, non-addictive, non-sedative drugs that can be administered in various ways (topically, orally, intravenously) to treat multiple pain states. Our lead program in this area is KD7040, a topically administered iNOS inhibitor that will treat neuropathic pain.