Kalypsys is searching for top talent to join our team in the following positions. Send your resume to [email protected].
This individual will be responsible for the pharmacological evaluation of novel therapeutics to treat diabetes, dyslipidemia, obesity and other related metabolic disorders. Responsibilities will include establishing and validating relevant disease models, developing in vivo/ex vivo pharmacodynamic markers suitable to drive structure activity relationships and provide pharmacological evaluation of test compounds in relevant disease models. This individual will organize and supervise work of a small group of scientists and summarize and communicate results both to internal and external customers as needed.
The individual in this position will be responsible for lead identification and preclinical/clinical in vitro assessment of compound mechanism. Specifically, this individual will oversee the development, validation, and implementation of novel biochemical/cell-based assay formats and technologies for small molecule lead discovery and characterization in multiple therapeutic areas, including Metabolic Diseases, Pain, and Inflammation. In addition, the individual will be responsible for the development of in vitro biomarker assays for the assessment of compound effects from human clinical samples. The individual will supervise at least one Ph.D. level and four B.S/M.S. level scientists associated with the structure-based drug design, assay development/ultra-high throughput screening, and clinical biomarker teams. This scientist will be required to work intimately in large, multi-disciplinary discovery and development teams, to report data in written and verbal format to the senior scientific management team in the relevant forums, and to interface with alliance partners.
Kalypsys' informatics group develops software to support drug discovery, including ultra-high-throughput assays, chemistry, biology, and analytical chemistry. We acquire, create and deploy software that enhances scientific quality, throughput, and originality. Meeting these objectives simultaneously is challenging. Our systems must be robust. Software must prevent inaccurate information from being recorded, yet be flexible to support evolving science. Active communication with scientist-users, as well as consistent testing and curation make our objectives attainable. To increase our strength in these areas we are recruiting a support scientist.
Responsibilities will include assessment of efficacy of novel therapeutics for metabolic diseases (diabetes, dyslipidemia, atherosclerosis and obesity) using a variety of in vivo animal models and ex vivo biochemical and/or molecular biological techniques. This will involve drug administration, behavioral observations as necessary, collection of tissues and/or body fluids for measures of drug efficacy and utilization of surrogate biomarkers of response. To this end, standard molecular biology and biochemistry techniques such as protein extraction, Western blotting, immunohistochemistry, gene expression and lipid biochemistry will be used to reveal both drug response and mechanism of action. Experience in islet isolation and hyperinsulinemis/euglycemic clamp studies in rodent models is a plus. The incumbent will have, expertise in experimental design, conduct, analysis and summarization of data, ability to effectively communicate results to project teams and contribute to project reports on a need basis.
The position will involve coordinating and conducting drug discovery research on specified targets and/or pathways in the therapeutic areas of pain and inflammation in collaboration with other members of the organization. The position may involve directing one or more research associates in the design and development of assays for primary and secondary screening of relevant targets (biochemical & cell-based), to characterize lead chemical series in biological assays, and to provide biology support to multidisciplinary drug discovery and preclinical development teams. Individual will report data in written and verbal format to senior scientific staff in relevant corporate and scientific forums.
Senior Scientist position requires the following minimum background combination of educational/job experiences:
We are currently seeking a highly motivated developer to help build and expand our suite of informatics tools. A successful candidate will be a strong leader, an independent problem solver, a creative thinker, is able to articulate their thoughts in a group setting and stays current with the latest advances in Java and web technologies. The candidate must write superior-quality code and play a significant role in software architecture, planning and management of projects. Strong emphasis is placed on cheminformatics and computational chemistry. Experience with chemically intelligent systems and pharmacological data is a plus.
The Associate Director (AD) position will be responsible for leading multiple development teams as Project Leader. The AD will effectively bridge the Discovery and Translation Medicine functions of the company, facilitating seamless progression of projects through the Kalypsys Stages and Gates. The Associate Director will contribute to global program management initiatives and should be flexible and opportunistic in taking on new challenges in a fast-paced small company environment.
Performs the following tasks independently: